The goal of the Minicell project is to construct a bacterial drug delivery system. Toward this goal, this project will develop improved computational and chemical tools for reliably designing, synthesizing, and executing genomes, and use these tools to construct a predictable, efficient cellular chassis for future engineering such as drug delivery. The project has five specific aims:

  • Extensively characterize the individual molecular components of M. pneumoniae,
  • Develop a whole-cell model of M. pneumoniae with expanded scope and improved accuracy,
  • Use the model to design a non-pathogenic strain that could be a chassis for future engineering,
  • Use in-yeast genome editing and transplantation to construct this optimized strain, and
  • Characterize the growth and virulence of the optimized stain and use this data to refine the model.

The Minicell project is a collaboration among five leading systems and synthetic biology research groups from the Center for Regulatory Genomics in Barcelona, the University of Göttingen in Göttingen, the Icahn School of Medicine at Mount Sinai in New York, the National Institute for Agricultural Research in Bordeaux, and Stanford Unversity in Stanford.

News

  • March 26, 2018: MiniCell consortium met at INRA
  • September 4-7, 2017: MiniCell consortium held the 2017 Whole-Cell Modeling Summer School at the Center for Genomic Regulation
  • September 4, 2017: MiniCell consortium met at the Center for Genomic Regulation
  • April 19, 2017: MiniCell consortium met online
  • October 24, 2016: MiniCell consortium met online
  • June 27, 2016: MiniCell consortium met online
  • April 11, 2016: MiniCell consortium met at the Center for Genomic Regulation
  • April 3-8, 2016: MiniCell consortium held the 2016 Whole-Cell Modeling Summer School at the Center for Genomic Regulation
  • October 25, 2015: MiniCell consortium met at the University of Göttingen
  • June 30, 2015: MiniCell consortium held its kickoff meeting
Center for Regulatory Genomics University of Gottingen Icahn School of Medicine at Mount Sinai National Institute for Agricultural Research University of Bordeaux
ERASynBio The Ministry of Economy and Competitiveness, Spain Federal Ministry of Education and Research, Germany National Science Foundation, USA The Centre National de la Recherche Scientifique, France
© Minicell Consortium 2015. Last updated March 30, 2018, 9:08 a.m..